La bibliografia riguarda gli studi effettuati in collaborazione con il Progetto Mielina.
In grassetto i membri del gruppo di lavoro del Progetto Mielina

2001

Gago N, Akwa Y, Sananes N, Guennoun R, Baulieu EE, El-Etr M, Schumacher M.: Progesterone and the oligodendroglial lineage: Stage dependent biosynthesis and metabolism. Glia. 2001

Guennoun R, Benmessahel Y, Delespierre B, Gouezou M, Rajkowski KM, Baulieu EE, Schumacher M.: Progesterone stimulates Krox-20 gene expression in schwann cells. Molecular Brain Research.

Lobsiger CS, Smith PM, Buchstaller J, Schweitzer B, Franklin RJM, Suter U, Taylor V (2001) SpL201: A conditionally-immortalised Schwann Cell precursor line that generates myelin. Glia.

Mercier G, Turque N, Schumacher M.: Early activation of transcription factor expression in Schwann cells by progesterone. Brain Research Molecular Brain Research.

Robert F, Guennoun R, Desarnaud F, Do-Thi A, Benmessahel Y, Baulieu EE, Schumacher M.: Synthesis of progesterone in Schwann cells, regulation by neurons. European Journal of Neuroscience 2001.

Smith PM, Franklin RJM (2001): The effect of immunosuppressive protocols on spontaneous remyelination following toxin-induced demyelination. Journal of Neuroimmunology.

Smith PM, Lakatos A, Barnett SC, Jeffery ND, Franklin RJM (2001): Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS. Experimental Neurology, 176: 402-406.

Smith PM, Sim FJ, Barnett SC, Franklin RJM (2001) SCIP/Oct-6: Krox-20 and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells. Glia.

Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA.: In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnology.

2000

Blakemore WF, Gilson JM, Crang AJ.: Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous cells. Journal of Neuroscience Research.

Desarnaud F, Bidichandani S, Patel PI, Baulieu EE, Schumacher M.: Glucocorticosteroids stimulate the activity of the promoters of peripheral myelin protein 22 and protein zero genes in schwann cells. Brain Research.

Kato T, Honmou O, Uede T, Hashi K, Kocsis JD.: Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord. Glia.

Milward EA, Zhang SC, Zhao M, Lundberg C, Ge B, Goetz BD, Duncan ID.: Enhanced proliferation and directed migration of oligodendroglial progenitors co-grafted with growth-factor secreting cells. Glia.

Nait-Oumesmar B, Lachapelle F, Decker L, Baron-Van Evercooren A.: Do CNS axons remyelinate? Pathology of Biology (Paris).

Shields SA, Blakemore WF, Franklin RJ.: Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain. Journal of Neuroscience Research.

Zhang SC, Duncan ID.: Remyelination and restoration of axonal function by glial cell transplantation. Progress in Brain Research.

1999

Jeffery ND, Crang AJ, O'Leary MT, Hodge SJ, Blakemore WF.: Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord. European Journal of Neuroscience.

Grever WE, Zhang SC, Ge B, Duncan ID.: Fractionation and enrichment of oligodendrocytes from developing human brain. Journal of Neuroscience Research.

Learish RD, Brustle O, Zhang SC, Duncan ID.: Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin. Annals of Neurology.

Schwartz CE, Vollmer T, Lee H.: Reliability and validity of two self-report meansures of impairment and disability for MS. North American Research Consortium on Multiple Sclerosis Outcomes Study Group. Neurology.

Sheremata WA, Vollmer TL, Stone LA, Willmer-Hulme AJ, Koller M.: A safety and pharmacokinetic study of intravenous natalizumab in patients with MS. Neurology.

Woodruff RH, Franklin RJ.: Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocebroside: a comparative study. Glia.

Zhang SC, Ge B, Duncan ID.: Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. Proceedings of the National Academy of Sciences USA.

1998

Agresti C, Bernardo A, Del Russo N, Marziali G, Battistini A, Aloisi F, Levi G, Coccia EM.: Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes. European Journal of Neuroscience.

Avellana-Adalid V, Bachelin C, Lachapelle F, Escriou C, Ratzkin B, Baron-Van Evercooren A.: In vitro and in vivo behaviour of NDF-expanded monkey Schwann cells. European Journal of Neuroscience.

Brüstle O, Choudhary K, Karram K, Hüttner A, Murray K, Dubois-Dalcq M, McKay RD.: Chimeric brains generated by intraventricular transplantation of human brain cells into embryonic rats. Nature Biotechnology. 16(11):1040-1044.

Desarnaud F, Do Thi AN, Brown AM, Lemke G, Suter U, Baulieu EE, Schumacher M.: Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells. Journal of Neurochemistry.

Duan Wm, Widner H, Cameron RM, Brundin P.: Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat. Supplement to the European Journal of Neuroscience.

Desarnaud F, Do-Thi AN, Brown AM, Lemke G, Suter U, Baulieu EE, Schumacher M. : Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 (PMP22) and protein zero genes in Schwann cells. Journal of Neurochemistry.

Fanarraga ML, Griffiths IR, Zhao M, Duncan ID.: Oligodendrocytes are not inherently programmed to myelinate a specific size of axon. Journal of Comparative Neurology.

Imaizumi T, Lankford KL, Waxman SG, Greer CA, Kocsis JD.: Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. Journal of Neuroscience.

Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB, Vollmer T, Weiner LP, Wolinsky JS. : Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Neurology.

Li DW, Duncan ID. The immune status of the myelin deficient rat and its immune responses to transplanted allogenic glial cells. Journal of Neuroimmunology.

Kemp S, Wei HM, Lu JF, Braiterman LT, McGuinness MC, Moser AB, Watkins PA, Smith KD. : Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy. Nature Medicine.

Singh I, Khan M, Key L, Pai S. : Lovastatin for X-Linked Adrenoleukodystrophy. New England Journal of Medicine.

Spassky N, Goujet-Zalc C, Parmantier E, Olivier C, Martinez S, Ivanove A, Ikenaka K, Macklin W, Cerruti I, Zalc B, Thomas J. : Multiple restricted origin of oligodendrocytes. Journal of Neuroscience.

Zhang SC, Lipsitz D, Duncan ID.: Self-renewing canine oligodendroglial progenitor expanded as oligospheres. Journal of Neuroscience Research.

1997

Althaus HH, Hempel R, Kloppner S, Engel J, Schmidt-Schultz T, Kruska L, Heumann R. : Nerve growth factor signal transduction in mature pig oligodendrocytes. Journal of Neuroscience Research.

Archer DR, Cuddon PA, Lipsitz D, Duncan ID.: Myelination of the canine central nervous system by glial cell transplantation: a model for repair of human myelin disease. Nature Medicine.

Baron-Van Evercooren A, Avellana-Adalid V, Lachapelle F, Liblau R. : Schwann cell transplantation and myelin repair of the CNS. Multiple Sclerosis.

Baulieu EE, Schumacher M.: Neurosteroids, with special reference to the effect of progesterone on myelination in peripheral nerves. Multiple Sclerosis.

Baron-Van Evercooren A.: Avellana-Adalid V, Lachapelle F, Liblau R. Schwann cell transplantation and myelin repair of the CNS. Multiple Sclerosis.

Restuccia D, Di Lazzaro V, Valeriani M, Oliviero A, Le Pera D, Barba C, Cappa M, Bertini E, Tonali P. : Abnormalities of somatosensory and motor evoked potentials in adrenomyeloneuropathy: comparison with magnetic resonance imaging and clinical findings. Neurochemical Research. 22(3):327-331.

Duncan ID, Grever WE, Zhang SC.: Repair of myelin disease: strategies and progress in animal models. Molecular Medicine Today.

Franklin RJ, Barnett SC. :Do olfactory glia have advantages over Schwann cells for CNS repair? Journal of Neuroscience Research. 50(5):665-672.

Franklin RJ, Gilson JM, Blakemore WF.: Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system. Journal of Neuroscience Research, 50(2):337-344.

Guennoun R, Schumacher M, Robert F, Delespierre B, Gouezou M, Eychenne B, Akwa Y, Robel P, Baulieu EE.: Neurosteroids: Expression of functional 3 ß-Hydroxysteroid Dehydrogenase by rat sensory neurons and Schwann cells. European Journal of Neuroscience.

Hammang JP, Archer DR, Duncan ID.: Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment. Experimental Neurology.

Ludwin SK.: The pathobiology of the oligodendrocyte. Journal of Neuropathology and Experimental Neurology, 56(2):111-124.

Murray K, Dubois-Dalcq M.: Emergence of oligodendrocytes from human neural spheres. Journal of Neuroscience Research, 50(2):146-156.

Oumesmar BN, Vignais L, Baron-Van Evercooren A.: Developmental expression of platelet-derived growth factor-a receptor in neurons and glial cells of mouse CNS. Journal of Neuroscience.

Pedraza L, Fidler L, Staugaitis SM, Colman DR.: The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelination. Neuron, 18(4):579-589.

Rehncrona S.: A critical review of the current status and possible developments in brain transplantation. Advances and Technical Standards in Neurosurgery, 23:3-46.

1996

Blakemore WF, Franklin RJ, & Bayley S. : Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in x-irradiated and damaged spinal cord but not in normal spinal cord. Experimental Neurology. 137:263-276.

Duncan ID.: Glial cell transplantation and remyelination of the central nervous system. Neuropathology and Applied Neurobiology.

Duncan ID, Guo Z, Yang N-S, Jiao S, Sun J, et al. : Efficient and sustained transgene expression in mature rat oligodendrocytes in primary culture. Journal of Neuroscience Research, 43(1):32-41.

Hajihosseini M, Tham TN, Dubois-Dalcq M.: Origin of oligodendrocytes within the human spinal cord. Journal of Neuroscience, 16(24):7981-7994.

Honmou O, Felts PA, Waxman SG, Kocsis JD.: Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous schwann cells. Journal of Neuroscience, 16(10):3199-3208.